My research aims are to understand the effects of ageing on neuromuscular and cognitive aspects of mobility (i.e., physical function and physical activity) and to implement this knowledge with assistive technology to maintain and promote mobility of older individuals in their own environment. In my research projects, I combine experimental and field studies to reveal determinants for mobility problems and falls on the short and on the long term, i.e. within seconds and over months.
I have contributed in the understanding of underlying neuromechanical, physiological and cognitive factors for balance control and falls and targets for interventions. I have contributed to the understanding of underlying neuromechanical, physiological and cognitive mechanicsms for decline of mobility with age, in identifying (individual) predictors for mobility decline (among which fall risk) and targets for intervention, in using technological instruments to assess and interact with daily physical function and activity and in improving mobility of older individuals in their environment.
My current research approaches are experimental studies (neuromuscular and biomechanical analyses), epidemiological studies (prediction models based on longitudinal cohort data), implementation of technological devices (e.g. accelerometry, kinect, smartphones, smartwatches) and interventions on fall prevention and active ageing in daily life behaviour. Examples of my current projects are my VIDI project "Falling: a mismatch between self-perceived and actual abilities in older adults?" and the EU PreventIT programme.
I obtained my PhD in 2004 from the Vrije Universiteit Amsterdam, based on thesis entitled "Recovery from a trip in young an older adults". I have been affiliated to the faculty and department of Human Movement Sciences at this university since to continue my work on the effects of ageing on balance control and falls. I was appointed as full professor in Mobility in Ageing in 2016. I gratefully received a personal VENI grant (2006), a TOP grant (2009), a VIDI grant (2014) and Aspasia grant (2015), all by the Dutch Netherlands Organisation for Scientific Research (NWO). I was a PhD supervisor in the Erasmus Mundus Joint Doctorate Programme Move-Age and currently am a co-PI in the EU Horizon 2020 programme PreventIT.
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Excerpts of scientific work
Distinct trajectories of individual physical performance measures across nine years in 60- to 70-year-old adults
Hoekstra, T., Rojer, A. G. M., van Schoor, N. M., Maier, A. B. & Pijnappels, M., 13 Feb 2020, In : The journals of gerontology. Series A, Biological sciences and medical sciences.
- Consistency and test–retest reliability of stepping tests designed to measure self-perceived and actual physical stepping ability in older adults
- Does misjudgement in a stepping down paradigm predict falls in an older population?
- Quality of daily-life gait: Novel outcome for trials that focus on balance, mobility, and falls
- Creating and Validating a Shortened Version of the Community Balance and Mobility Scale for Application in People Who Are 61 to 70 Years of Age
- Catch the ruler: concurrent validity and test–retest reliability of the ReacStick measures of reaction time and inhibitory executive function in older people
The Adapted Lifestyle-Integrated Functional Exercise Program for Preventing Functional Decline in Young Seniors: Development and Initial Evaluation
Schwenk, M., Bergquist, R., Boulton, E., Van Ancum, J. M., Nerz, C., Weber, M., Barz, C., Jonkman, N. H., Taraldsen, K., Helbostad, J. L., Vereijken, B., Pijnappels, M., Maier, A. B., Zhang, W., Becker, C., Todd, C., Clemson, L. & Hawley-Hague, H., Jul 2019, In : Gerontology. 65, 4, p. 362-374 13 p.
Development of a clinical prediction model for the onset of functional decline in people aged 65-75 years: pooled analysis of four European cohort studies
Jonkman, N. H., Colpo, M., Klenk, J., Todd, C., Hoekstra, T., Del Panta, V., Rapp, K., Van Schoor, N. M., Bandinelli, S., Heymans, M. W., Mauger, D., Cattelani, L., Denkinger, M. D., Rothenbacher, D., Helbostad, J. L., Vereijken, B., Maier, A. B. & Pijnappels, M., 27 Jun 2019, In : BMC Geriatrics. 19, 1, p. 1-12 12 p., 179.
- Effects of ankle muscle fatigue and visual behavior on postural sway in young adults
- Lack of Knowledge Contrasts the Willingness to Counteract Sarcopenia Among Community-Dwelling Adults
Protocol for the PreventIT feasibility randomised controlled trial of a lifestyle-integrated exercise intervention in young older adults
Taraldsen, K., Stefanie Mikolaizak, A., Maier, A. B., Boulton, E., Aminian, K., Van Ancum, J., Bandinelli, S., Becker, C., Bergquist, R., Chiari, L., Clemson, L., French, D. P., Gannon, B., Hawley-Hague, H., Jonkman, N. H., Mellone, S., Paraschiv-Ionescu, A., Pijnappels, M., Schwenk, M., Todd, C. & 4 othersYang, F. B., Zacchi, A., Helbostad, J. L. & Vereijken, B., 20 Mar 2019, In : BMJ Open. 9, 3, p. 1-20 20 p., e023526.
- Gait speed assessed by a 4-m walk test is not representative of daily-life gait speed in community-dwelling adults
- Comparison of Standard Clinical and Instrumented Physical Performance Tests in Discriminating Functional Status of High-Functioning People Aged 61⁻70 Years Old
- Gait stability in response to platform, belt, and sensory perturbations in young and older adults
- Predictors of metabolic syndrome in community-dwelling older adults
- Do older adults select appropriate motor strategies in a stepping-down paradigm?
- Instrumented Assessment of Physical Activity Is Associated With Muscle Function but Not With Muscle Mass in a General Population
- The effect of walking speed on quality of gait in older adults
- Where to step? Contributions of stance leg muscle spindle afference to planning of mediolateral foot placement for balance control in young and old adults
- The association between age and accelerometry-derived types of habitual daily activity: An observational study over the adult life span in the Netherlands
- Concurrent validity and reliability of the Community Balance and Mobility scale in young-older adults
- Complexity of daily physical activity is more sensitive than conventional metrics to assess functional change in younger older adults
- Associations between bicycling and reduced fall-related physical performance in older adults
- Muscle mass and muscle strength are associated with pre- and post-hospitalization falls in older male inpatients: a longitudinal cohort study
- Self-perceived gait stability modulates the effect of daily life gait quality on prospective falls in older adults
- Improved prediction of falls in community-dwelling older adults through phase-dependent entropy of daily-life walking
- Predicting Trajectories of Functional Decline in 60- to 70-Year-Old People
- On the validity and consistency of misjudgment of stepping ability in young and older adults
- Fractional stability of trunk acceleration dynamics of daily-life walking: Toward a unified concept of gait stability
- Behavioural activation by mental health nurses for late-life depression in primary care: A randomized controlled trial
Assessment of maximal handgrip strength: How many attempts are needed?
Reijnierse, E. M., de Jong, N., Trappenburg, M. C., Blauw, G. J., Butler-Browne, G., Gapeyeva, H., Hogrel, J. Y., Mcphee, J. S., Narici, M. V., Sipilä, S., Stenroth, L., van Lummel, R. C., Pijnappels, M., Meskers, C. G. M. & Maier, A. B., Jun 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 3, p. 466-474 9 p.
- Motivation for Mobility: further steps in research on mobility in ageing
- Instrumented assessment of physical activity and its association with muscle mass, handgrip strength and gait speed in a general population
- Over-and underestimation of older adults: How older adults judge their own gait ability
- Detecting not-wearing periods during activity monitoring
- Assessing gait stability: The influence of state space reconstruction on inter- and intra-day reliability of local dynamic stability during over-ground walking.
- Innovatieve tooling: het voorspellen en voorkomen van vallen bij ouderen
- Sensitivity of Local Dynamic Stability of Over-Ground Walking to Balance Impairment Due to Galvanic Vestibular Stimulation.
- Sensitivity of trunk variability and stability measures to balance impairments induced by galvanic vestibular stimulation during gait.
- Gait stability and variability measures show effects of impaired cognition and dual tasking in frail people
Physiological and cognitive mediators for the association between self-reported depressed mood and impaired choice stepping reaction time in older people.
Kvelde, T., Pijnappels, M. A. G. M., Delbaere, K., Close, J. C. & Lord, S. R., 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65A, 5, p. 538-544
Which Types of Activities Are Associated With Risk of Recurrent Falling in Older Persons?
Peeters, G. M. E. E., Verweij, L. M., van Schoor, N. M., Pijnappels, M. A. G. M., Pluijm, S. M. F., Visser, M. & Lips, P., 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65A, 7, p. 743-750
- The association between choice stepping reaction time and falls in older adults--a path analysis model
- Armed against falls: the contribution of arm movements to balance recovery after tripping
- Consequences of lower extremity and trunk muscle fatigue on balance and functional tasks in older people: A systematic literature review
- Effects of conflicting constraints and age on strategy choice in stepping down during gait
- Training meest effectief voor afname valrisico.
- Mechanics of toe and heel landing in stepping down in ongoing gait
Stumbling reactions in man: Influence of corticospinal input
Keck, M. E., Pijnappels, M., Schubert, M., Colombo, G., Curt, A. & Dietz, V., Jun 1998, In : Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control. 109, 3, p. 215-223 9 p.
- Cortical facilitation of cutaneous reflexes in leg muscles during human gait
Excerpts of scientific work
Hip muscle function and mediolateral balance control in older adults
Arvin, M., 2016
A walk on the wild side: Fall-risk assessment from daily-life gait
Rispens, S. M., 2015
Predicting Falls: Amount and Quality of Daily-life Gait as Risk Factors
van Schooten, K. S., 2014
Mediolateral Balance Assessment in older Adults: MELBA
Cofre Lizama, L. E., 2014
Impact of muscle fatigue on mechanics and motor control of walking
Barbieri, F. A., 2013
- Recovery from a trip in young and older adults: mechanics and control of the support limb